摘要
Abstract
Objective To investigate the effect of trimetazidine on the efficacy and corrected QT dispersion ( QTcd ) in patients with unstable angina pectoris. Methods Totally 78 patients with unstable angina pectoris were divided as trial group ( 38 cases ) and control group ( 40 cases ) according to the random number table. The patients in the trial received trimetazidine treatment , while those in the control group received non - trimetazidine treatment. The changes of QTcd, myocardial ischemia, left ventricular ejection fraction ( LVEF ), left ventricular end - diastolic diameter ( LVEDD ), cardiovascular events, and adverse drug reactions in the two groups before treatment and after 3 - month treatment were observed. Results After 3 - month treatment , the levels of amplitude of ST segment depression, T wave inversion amplitude, LVEF, and LVEDD of patients in the two groups were obviously improved ( P < 0. 05 ); and the levels of amplitude of ST segment depression, T wave inversion amplitude, LVEF, and LVEDD of patients in the trial group were significantly better than those in the control group ( P <0. 05 ). QTcd of patients in the trial group was significantly lower than that in the control group after 1 - month and 3 - month treatment ( P < 0. 05 ). The incidence of cardiovascular events of patients in the trial group was significantly lower than that in the control group in the three months period ( P <0. 05 ). Trimetazidine induced no obvious adverse reactions. Conclusion Trimetazidine can significantly improve myocardial ischemia and left ventricular function, reduced QTcd and the incidence of cardiovascular events for patients with unstable angina pectoris. It can improve short - term prognosis of the patients, being well tolerated, and with no significant adverse reactions.关键词
心绞痛,不稳定型/校正QT离散度/曲美他嗪Key words
Angina, unstable/ Corrected QT dispersion/ Trimetazidine分类
医药卫生
