摘要
Abstract
Objective To investigate the condition of pathogenic bacteria in acquired respiratory infection in ICU and their drug resistance, so as to provide basis for control of the acquired infection clinically and in ICU. Methods Totally 3 087 sputum samples gained from ICU were cultured and then separated 1 028 strains of pathogenic bacteria. The bacterium identification instrument by the French BioMerieux company was used to identify them and then to conduct the drug sensitivity. Results In the 1 028 strains of the pathogenic bacterium, 784 ( 76. 3% ) were gram negative bacillus, 98 ( 9. 5% ) were gram positive bacillus, and 146 ( 14. 2% ) were fungus. In the gram negative bacillus the most common were Pseudomonas aeruginosa and Burk-holderia cepacia, with 183 strains for each, accounting for 17. 8%. In the gram positive bacillus, Staphylococcus aureus was the major one, with 66 strains, accounting for 6. 4% . Candida albicans was the most common pathogen, with 104 strains, accounting for 10. 1 % . The results of drug sensitivity test showed that the main pathogenic bacteria presented high drug resistance, and usually multi - drug resistance. Gram negative bacilli, except for the Stenotrophomonas maltophilia, were most sensitive to Carbapenems, with a drug resistance rate of less than 18. 5% , or even zero. Gram positive bacilli were highly sensitive to Van-comycin and Iinezolid, but had a higher resistance rate for Penicillin and Erythromycin. Fungi were of higher sensibility to the common antifungal agents. Conclusion Most pathogenic bacteria of the acquired infection in the lower respiratory tract in ICU are of multi - drug resistance. Rational use of antibiotics should be carried out according to etiology and drug resistant data of pathogenic bacteria in order to control infections effectively and reduce new drug resistant bacterium.关键词
重症监护病房/获得性下呼吸道感染/病原菌/耐药性Key words
Intensive care unit/ Acquired lower respiratory tract infection/ Pathogenic bacterium/ Drug resistance分类
医药卫生
