中国全科医学2012，Vol.15Issue(17)：1937-1939,3.DOI:10.3969/j.issn.1007-9572.2012.06.051
奥沙利铂联合氟尿嘧啶和亚叶酸钙行新辅助化疗治疗进展期胃癌的临床疗效研究
Oxaliplatin in Combination with Fluorouracil and Calcium Folinate as Neoadjuvant Chemotherapy for Patients with Advanced Gastric Cancer
谭永刚 1耿东华 2苏拓 3李凯 1王颖1
作者信息
- 1. 110004,辽宁省沈阳市,中国医科大学附属盛京医院肿瘤科
- 2. 110004,辽宁省沈阳市,中国医科大学附属盛京医院普通外科
- 3. 北京市通州区潞河医院普通外科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and toxicity of oxaliplatin combined with fluorouracil and leucovorin as neoadjuvant chemotherapy ( NACT ) in treating advanced stomach cancer. Methods Totally 134 patients with advanced gastric cancer from Shengjing Hospital, China Medical University, and Luhe Hospital ( Tongzhou District, Beijing ), were divided into NACT group ( n =58 ) and control group ( receiving conventional surgery and postoperative chemotherapy; n =76 ). Results The treatment responses in the NACT group included CR ( n = 6, 10. 3% ), PR ( n = 33 , 56. 9% ), SD ( n = 14, 24. 1% ), and PD ( n = 5 , 8. 6% ), yielding a total effective rate of 67. 2% ; meanwhile, the toxicity can be tolerated. The proportions of surgical resection and radical resection rates were significantly lower in NACT group than the control group ( P <0. 05 ). The follow - up rate was 93. 4% ( n =71 ) in the control group and 91. 4% ( n = 53 ) in the NACT group, during which the 3 - year survival rate showed significant difference ( P = 0. 008 ). Conclusion Oxaliplatin combined with fluorouracil and leucovorin as NACT is effective and safe in treating advanced gastric cancer in terms of resection rate, proportion of radical surgery, and 3 -year survival.关键词
胃肿瘤/抗肿瘤联合化疗方案/5-氟尿嘧啶/亚叶酸钙/奥沙利铂Key words
Stomach neoplasms/ Antineoplastis combined coemotherapy protocols/ 5 - Fluorouracil/ Calcium folinate/ Oxaliplatin for injection分类
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谭永刚,耿东华,苏拓,李凯,王颖..奥沙利铂联合氟尿嘧啶和亚叶酸钙行新辅助化疗治疗进展期胃癌的临床疗效研究[J].中国全科医学,2012,15(17):1937-1939,3.
