中国全科医学2012，Vol.15Issue(17)：1945-1948,4.DOI:10.3969/j.issn.1007-9572.2012.06.054
非ST段抬高心肌梗死和不稳定心绞痛患者血浆脂肪激素Chemerin水平及其影响因素研究
Plasma Chemerin Levels in Patients with Non-ST Segment Myocardial Infarction/Unstable Angina and Its Influencing Factors
范书英 1王丹 1王勇 1于长安 1黎娜 1郑金刚 1彭文华 1陈莉 1车勇 1赵霞 1赵桂茹1
作者信息
- 1. 100029,北京市,中日友好医院心内科
- 折叠
摘要
Abstract
Objective To examine the plasma chemerin levels in patients with non - ST segment myocardial infarction/unstable angina ( NSTEMI/UA ) and its influencing factors. Methods The subjects were divided into three groups according to coronary angiography and the clinical presentation: control group ( n = 44 ), stable coronary heart disease group ( n = 40 ), and NSTEMI/UA group ( n = 37 ). Plasma chemerin level was detemined by ELISA; meanwhile, free blood glucose ( FBG ), blood lipids, cretinine ( Cr ), high - sensitivity C - reactive protein ( hs - CRP ), white blood cell ( WBC ), plasma fibrinogen and other factors were also analyzed. Results Compared with the control group and stable coronary heart disease group, NSTEMI/UA group has significantly higher plasma chemerin level [ ( 229. 45 ±25. 47 ) ng/ml, ( 203. 82 ±9. 89 ) ng/ ml, ( 214. 53 ± 12. 24 ) ng/ml, P <0. 05 ]. Pearson analysis demonstrated that plasma chemerin level was positively correlated with heart rate ( HR ), WBC, neutrophil, hs - CRP, fibrinogen, FBG, and Cr ( r = 0.605, 0.583, 0.610, 0.608, 0. 553, 0. 558 and 0. 674, P <0. 001 ). Conclusion Plasma chemerin level is significantly elevated in NSTEMI/UA patients and is correlated with HR, SBP, WBC, neutrophil, hs - CRP, fibrinogen, FBG, and Cr. Chemerin may be associated with atherosclerotic vulnerable plaque and play a role in thrombosis.Chemerin; Non ST segment elevated myocardial infarction; Unstable angina关键词
Chemerin/非ST段抬高性心肌梗死/心绞痛Key words
Chemerin/ Non ST segment elevated myocardial infarction/ Unstable angina分类
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范书英,王丹,王勇,于长安,黎娜,郑金刚,彭文华,陈莉,车勇,赵霞,赵桂茹..非ST段抬高心肌梗死和不稳定心绞痛患者血浆脂肪激素Chemerin水平及其影响因素研究[J].中国全科医学,2012,15(17):1945-1948,4.
