首页|期刊导航|中国神经再生研究（英文版）|Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis
中国神经再生研究（英文版）2012，Vol.7Issue(13)：1013-1019,7.DOI:10.3969/j.issn.1673-5374.2012.13.008
Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis
Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis
摘要
Abstract
A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibited the expression of the cell cycle regulatory proteins, survivin, cyclinD1, c-Myc and CDK4 and enhanced the sensitivity of U-87MG cells to paclitaxel.关键词
RNA interference/paclitaxel/survivin/glioma/neural regenerationKey words
RNA interference/paclitaxel/survivin/glioma/neural regeneration引用本文复制引用
Yunliang Xie,Yanbo Liu,Weigao Shen,Bo Zhang,Qun Liu..Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis[J].中国神经再生研究（英文版）,2012,7(13):1013-1019,7.基金项目
The research was supported by the Natural Science Foundation of Jilin Province,No.2011146,2012150 and 201215100 and the Natural Science Foundation of Jilin Technology Division,No.201133139 and 201032235. （）
