首页|期刊导航|中国神经再生研究（英文版）|Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice
中国神经再生研究（英文版）2012，Vol.7Issue(14)：1080-1087,8.DOI:10.3969/j.issn.1673-5374.2012-14-006
Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice
Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice
摘要
Abstract
Our previous research showed that octacosanol exerted its protective effects in 6-hydroxydopamine-induced Parkinsonian rats. The goal of this study was to investigate whether octacosanol would attenuate neurotoxicity in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)-treated C57BL/6N mice and its potential mechanism. Behavioral tests, tyrosine hydroxylase immunohistochemistry and western blot were used to investigate the effects of octacosanol in a mouse model of Parkinson's disease. Oral administration of octacosanol (100 mg/kg) significantly improved behavioral impairments in mice treated by MPTP and markedly ameliorated morphological appearances of tyrosine hydroxylase-positive neuronal cells in the substantia nigra. Furthermore, octacosanol blocked MPTP-induced phosphorylation of p38MAPK and JNK, but not ERK1/2. These findings implicated that the protective effects afforded by octacosanol might be mediated by blocking the phosphorylation of p38MAPK and JNK on the signal transduction in vivo. Considering its excellent tolerability, octacosanol might be considered as a candidate agent for clinical application in treating Parkinson's disease.关键词
Parkinson's disease/neuroprotecion/mitogen-activated protein kinase/c-Jun N-terminal kinase/p38MAPK/substantia nigra/neural regenerationKey words
Parkinson's disease/neuroprotecion/mitogen-activated protein kinase/c-Jun N-terminal kinase/p38MAPK/substantia nigra/neural regeneration引用本文复制引用
Tao Wang,Yanyong Liu,Nan Yang,Chao Ji,Piu Chan,Pingping Zuo..Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice[J].中国神经再生研究（英文版）,2012,7(14):1080-1087,8.基金项目
This work was supported by the grants from National Basic Research Program of China (973 Program),No.2007B507400,2010CB934002,2011CB504101,2011CBA00408 （973 Program）
the National Natural Science Foundation of China,No.81050025 （）
and the grant from the Ministry of Science and Technology of China Eleventh 5-year Plan-Technical Platform for Drug Development,No.2009ZX09303-8. （）
