首页|期刊导航|中国神经再生研究（英文版）|Effects of cytokines and chemokines on migration of mesenchymal stem cells following spinal cord injury
中国神经再生研究（英文版）2012，Vol.7Issue(14)：1106-1112,7.DOI:10.3969/j.issn.1673-5374.2012-14-010
Effects of cytokines and chemokines on migration of mesenchymal stem cells following spinal cord injury
Effects of cytokines and chemokines on migration of mesenchymal stem cells following spinal cord injury
摘要
Abstract
We investigated the effects of cytokines and chemokines and their associated signaling pathways on mesenchymal stem cell migration after spinal cord injury, to determine their roles in the curative effects of mesenchymal stem cells. This study reviewed the effects of tumor necrosis factor-α, vascular endothelial growth factor, hepatocyte growth factor, platelet-derived growth factor, basic fibroblast growth factor, insulin like growth factor-1, stromal cell-derived factor and monocyte chemoattractant protein-1, 3 during mesenchymal stem cell migration to damaged sites, and analyzed the signal transduction pathways involved in their effects on mesenchymal stem cell migration. The results confirmed that phosphatidylinositol 3-kinase/serine/threonine protein kinases and nuclear factor-κB play crucial roles in the migration of mesenchymal stem cells induced by cytokines and chemokines.关键词
spinal cord injury/mesenchymal stem cells/migration/cytokine/chemokine/signaling pathway/neural regenerationKey words
spinal cord injury/mesenchymal stem cells/migration/cytokine/chemokine/signaling pathway/neural regeneration引用本文复制引用
Longyun Li,Xiaoyu Yang,Maoguang Yang,Chunxin Wang,Qiheng Zhao,Jian Liu,Chuanguo Zhan,Zhi Liu,Xuepeng Li,Weihua Wang..Effects of cytokines and chemokines on migration of mesenchymal stem cells following spinal cord injury[J].中国神经再生研究（英文版）,2012,7(14):1106-1112,7.基金项目
This project was funded by the National Natural Science Foundation of China (Establishment of goat models of ischemic injury via corticospinal tract projection tract and action mechanism of MPA1B axon guidance during BMSC migration in the spinal cord),No.30972153. （Establishment of goat models of ischemic injury via corticospinal tract projection tract and action mechanism of MPA1B axon guidance during BMSC migration in the spinal cord）
