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Electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in the injured spinal cord of adult rats

Haiying Wu Min Hu Dekai Yuan Yunhui Wang Jing Wang Tao Li Chuanyun Qian

中国神经再生研究(英文版)2012,Vol.7Issue(15):1138-1144,7.
中国神经再生研究(英文版)2012,Vol.7Issue(15):1138-1144,7.DOI:10.3969/j.issn.1673-5374.2012.15.003

Electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in the injured spinal cord of adult rats

Electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in the injured spinal cord of adult rats

Haiying Wu 1Min Hu 2Dekai Yuan 2Yunhui Wang 1Jing Wang 1Tao Li 1Chuanyun Qian1

作者信息

  • 1. Department of Emergency and Intensive Care Unit, First Affiliated Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China
  • 2. Kunming University, Kunming 650118, Yunnan Province, China
  • 折叠

摘要

Abstract

A contusive model of spinal cord injury at spinal segment T8-9 was established in rats. Huantiao (GB30) and Huatuojiaji (Ex-B05) were punctured with needles, and endogenous neural stem cells were labeled with 5-bromo-2'-deoxyuridine (BrdU) and NG2. Double immunofluorescence staining showed that electroacupuncture markedly increased the numbers of BrdU+/NG2+ cells at spinal cord tissue 15 mm away from the injury center in the rostral and caudal directions. The results suggest that electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in rats with spinal cord injury.

关键词

endogenous oligodendrocyte progenitor cells/spinal cord injury/electroacupuncture/proliferation/remyelination/neural regeneration

Key words

endogenous oligodendrocyte progenitor cells/spinal cord injury/electroacupuncture/proliferation/remyelination/neural regeneration

引用本文复制引用

Haiying Wu,Min Hu,Dekai Yuan,Yunhui Wang,Jing Wang,Tao Li,Chuanyun Qian..Electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in the injured spinal cord of adult rats[J].中国神经再生研究(英文版),2012,7(15):1138-1144,7.

基金项目

This research was supported by the Study Science Foundation of the Department of Education,Yunnan Province,China,No.2011Y184 ()

the National Natural Science Foundation of China,No.10S090202 ()

Doctoral Innovation Foundation of Kunming Medical University,No.2011D01 ()

the Natural Science Foundation of Kunming University,No.XJ11L016. ()

中国神经再生研究(英文版)

OACSCDCSTPCD

1673-5374

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