首页|期刊导航|中国神经再生研究（英文版）|Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study
中国神经再生研究（英文版）2012，Vol.7Issue(15)：1151-1157,7.DOI:10.3969/j.issn.1673-5374.2012.15.005
Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study
Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study
摘要
Abstract
Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimental findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder.关键词
major depressive disorder/functional magnetic resonance imaging/facial expression recognition/antidepressant/neural regenerationKey words
major depressive disorder/functional magnetic resonance imaging/facial expression recognition/antidepressant/neural regeneration引用本文复制引用
Wenyan Jiang,Zhongmin Yin,Yixin Pang,Feng Wu,Lingtao Kong,Ke Xu..Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study[J].中国神经再生研究（英文版）,2012,7(15):1151-1157,7.基金项目
The study was supported by research grants from the National Natural Science Foundation of China (No.81071099),the Liaoning Science and Technology Foundation (No.2008225010-14),and Doctoral Foundation of the First Affiliated Hospital in China Medical University (No.2010). （No.81071099）
