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Paravertebral fascial massage promotes brain development of neonatal rats via the insulin-like growth factor 1 pathway

Zhongqiu Wen Wenqin Zeng Jingxing Dai Xin Zhou Chun Yang Fuhua Duan Yufeng Liu Huiying Yang Lin Yuan

中国神经再生研究(英文版)2012,Vol.7Issue(15):1185-1191,7.
中国神经再生研究(英文版)2012,Vol.7Issue(15):1185-1191,7.DOI:10.3969/j.issn.1673-5374.2012.15.010

Paravertebral fascial massage promotes brain development of neonatal rats via the insulin-like growth factor 1 pathway

Paravertebral fascial massage promotes brain development of neonatal rats via the insulin-like growth factor 1 pathway

Zhongqiu Wen 1Wenqin Zeng 1Jingxing Dai 1Xin Zhou 1Chun Yang 1Fuhua Duan 1Yufeng Liu 1Huiying Yang 1Lin Yuan1

作者信息

  • 1. Key Laboratory of Tissue Construction and Detection of Guangdong Province, Department of Anatomy, Southern Medical University, Guangzhou 510515, Guangdong Province, China
  • 折叠

摘要

Abstract

Massage in traditional Chinese medicine can promote body and brain development of premature and normal newborn infants. In the present study, neonatal rats (1 day old) underwent paravertebral fascial massage (15 consecutive days), followed by subcutaneous injection of insulin-like growth factor 1 receptor antagonist, JB1 (9 consecutive days). Paravertebral fascial massage significantly increased insulin-like growth factor 1 expression and cell proliferation in the subventricular zone of the lateral ventricle and dentate gyrus of the hippocampus. However, JB1 inhibited this increase. Results suggest that paravertebral fascial massage can promote brain development of neonatal rats via the insulin-like growth factor 1 pathway.

关键词

paravertebral fascial massage/insulin-like growth factor 1/neurogenesis/immunohistochemistry/neural regeneration

Key words

paravertebral fascial massage/insulin-like growth factor 1/neurogenesis/immunohistochemistry/neural regeneration

引用本文复制引用

Zhongqiu Wen,Wenqin Zeng,Jingxing Dai,Xin Zhou,Chun Yang,Fuhua Duan,Yufeng Liu,Huiying Yang,Lin Yuan..Paravertebral fascial massage promotes brain development of neonatal rats via the insulin-like growth factor 1 pathway[J].中国神经再生研究(英文版),2012,7(15):1185-1191,7.

基金项目

This study was supported by the National Basic Research Program of China (973 Program),No.2007CB512705 (973 Program)

the General Program for Youths of the National Nature science Foundation of China,No.30801464. ()

中国神经再生研究(英文版)

OACSCDCSTPCDSCI

1673-5374

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