中国神经再生研究（英文版）2012，Vol.7Issue(16)：1220-1227,8.DOI:10.3969/j.issn.1673-5374.2012.16.003
Granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells for the treatment of ischemic stroke
Granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells for the treatment of ischemic stroke
Xingjian Lin 1Yingdong Zhang 1Weiguo Liu 2Jingde Dong 1Jie Lu 1Qing Di 1Jingping Shi1
作者信息
- 1. Nanjing Medical University, Affiliated Nanjing Brain Hospital, Department of Neurology, Nanjing 210029, Jiangsu Province, China
- 2. Nanjing Medical University, Affiliated Nanjing First Hospital, Department of Neurology, Nanjing 210029, Jiangsu Province, China
- 折叠
摘要
Abstract
Adult, male, Sprague-Dawley rats were injected with granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells (GM-CSF-BMSCs) into the ischemic boundary zone at 24 hours after onset of middle cerebral artery occlusion. Results showed reduced infarct volume, decreased number of apoptotic cells, improved neurological functions, increased angiogenic factor expression, and increased vascular density in the ischemic boundary zone in rats that underwent GM-CSF-BMSCs transplantation compared with the BMSCs group. Experimental findings suggested that GM-CSF-BMSCs could serve as a potential therapeutic strategy for ischemic stroke and are superior to BMSCs alone.关键词
bone marrow stromal cells/granulocyte-macrophage colony-stimulating factor/gene transfection/ischemic stroke/transplantation/stem cells/neural regenerationKey words
bone marrow stromal cells/granulocyte-macrophage colony-stimulating factor/gene transfection/ischemic stroke/transplantation/stem cells/neural regeneration引用本文复制引用
Xingjian Lin,Yingdong Zhang,Weiguo Liu,Jingde Dong,Jie Lu,Qing Di,Jingping Shi..Granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells for the treatment of ischemic stroke[J].中国神经再生研究（英文版）,2012,7(16):1220-1227,8.
