首页|期刊导航|中国神经再生研究（英文版）|Spatiotemporal alterations of presynaptic elements in the retina after high intraocular pressure
中国神经再生研究（英文版）2012，Vol.7Issue(16)：1234-1240,7.DOI:10.3969/j.issn.1673-5374.2012.16.005
Spatiotemporal alterations of presynaptic elements in the retina after high intraocular pressure
Spatiotemporal alterations of presynaptic elements in the retina after high intraocular pressure
摘要
Abstract
A rat model of acute high intraocular pressure was established by injecting saline into the anterior chamber of the left eye. Synaptophysin expression was increased in the inner plexiform layer at 2 hours following injury, and was widely distributed in the outer plexiform layer at 3–7 days, and then decreased to the normal level at 14 days. This suggests that expression of this presynaptic functional protein experienced spatiotemporal alterations after elevation of intraocular pressure. There was no significant change in the fluorescence intensity and distribution pattern for synapse-associated protein 102 following elevated intraocular pressure. Synapse-associated protein 102 immunoreactivity was confined to the outer plexiform layer, while synaptophysin immunoreactivity spread into the outer plexiform layer and the outer nuclear layer at 3 and 7 days following injury. These alterations in presynaptic elements were not accompanied by changes in postsynaptic components.关键词
synaptophysin/synapse-associated protein 102/synaptic plasticity/elevated intraocular pressure/retina/neural regenerationKey words
synaptophysin/synapse-associated protein 102/synaptic plasticity/elevated intraocular pressure/retina/neural regeneration引用本文复制引用
Jufang Huang,Lihong Zhou,Hui Wang,Jia Luo,Kun Xiong,Leping Zeng,Dan Chen..Spatiotemporal alterations of presynaptic elements in the retina after high intraocular pressure[J].中国神经再生研究（英文版）,2012,7(16):1234-1240,7.基金项目
This study was financially sponsored by the Ph.D.Programs Foundation of the Ministry of Education of China,No 20090162110019 （）
the Natural Science Foundation of Hunan Province,No.10JJ4023 （）
the Fundamental Research Funds for the Central Universities of China,No.2011QNZT128 （）
Graduate Scientific Research Innovation Projects of Hunan Province in 2011,No.CX2011B047. （）
