首页|期刊导航|中国神经再生研究（英文版）|Impulse magnetic stimulation facilitates synaptic regeneration in rats following sciatic nerve injury
中国神经再生研究（英文版）2012，Vol.7Issue(17)：1299-1303,5.DOI:10.3969/j.issn.1673-5374.2012.17.003
Impulse magnetic stimulation facilitates synaptic regeneration in rats following sciatic nerve injury
Impulse magnetic stimulation facilitates synaptic regeneration in rats following sciatic nerve injury
摘要
Abstract
The current studies describing magnetic stimulation for treatment of nervous system diseases mainly focus on transcranial magnetic stimulation and rarely focus on spinal cord magnetic stimula-tion. Spinal cord magnetic stimulation has been confirmed to promote neural plasticity after injuries of spinal cord, brain and peripheral nerve. To evaluate the effects of impulse magnetic stimulation of the spinal cord on peripheral nerve regneration, we compressed a 3 mm segment located in the middle third of the hip using a sterilized artery forceps to induce ischemia. Then, all animals un-derwent impulse magnetic stimulation of the lumbar portion of spinal crod and spinal nerve roots daily for 1 month. Electron microscopy results showed that in and below the injuryed segment, the inflammation and demyelination of neural tissue were alleviated, apoptotic cells were reduced, and injured Schwann cells and myelin fibers were repaired. These findings suggest that high-frequency impulse magnetic stimulation of spinal cord and corresponding spinal nerve roots promotes synaptic regeneration following sciatic nerve injury.关键词
impulse magnetic stimulation/experimental neuropathy/sciatic nerve lesion/neuroplasticity/neural regenerationKey words
impulse magnetic stimulation/experimental neuropathy/sciatic nerve lesion/neuroplasticity/neural regeneration引用本文复制引用
Sergey A. Zhivolupov,Miroslav M. Odinak,Nariman A. Rashidov,Ludmila S. Onischenko,Igor N. Samartsev,Anton A. Jurin..Impulse magnetic stimulation facilitates synaptic regeneration in rats following sciatic nerve injury[J].中国神经再生研究（英文版）,2012,7(17):1299-1303,5.基金项目
Ethical approval:All experimental procedures were approved by the Ethics Committee of the Military Medical Academy,Saint-Petersburg,Russia (protocol No.82,10.06.2009). （protocol No.82,10.06.2009）
