中国输血杂志2012，Vol.25Issue(2)：115-119,5.
HLA不全相合造血干细胞联合脐血移植治疗急性白血病的临床观察
Clinical study of the HLA-mismatched hematopoietic stem cell transplantation combined with Umbilical Cord Blood for the treatment of acute leukemia
摘要
Abstract
Objective To explore the effectiveness of HLA-mismatched hematopoietic stem cell transplantation combined with Umbilical Cord Blood transplantation in treatment of acute leukemia. Methods From June 2008 to December 2009,twenty patients with acute leukemia in our hospital received HLA-mismatched hematopoietic stem cell transplantation combined with Umbilical Cord Blood and fifty one patients received HLA-mismatched hematopoietic stem cell transplantation. Implantation level and recovery of bone marrow, transplantation-related complications and therapeutic effect were compared between the two groups. Results The average counts of nucleated cells in cord blood were 2. 96 × 107/kg and CD34+ cells were 2.99 x 105/ kg. One patients did not achieve engraftment in combined transplantation group. The mean time for absolute neutrophil count to be over 0.5 ×109/L was (12.6 ±2.50) d.and that of platelet count over 20× 109/L was (17.2 ±3. 70) d,respectively in the combination transplantation group,not significant different from those in the control group(P>0.05). The incidence of grade HI - IV severe acute graft versus host disease (GVHD) was 5.0% in combined transplantation group,lower than in control group(P <0. 05). One year OS in combined transplantation group was 80% better than the 72.5% in the control group(P<0.05). However.no statistical differences were observed in chronic GVHD, infection and 1 -year relapse between the two groups (P > 0.05). Conclusion HLA-mismatched hematopoietic stem cell transplantation combined with Umbilical Cord Blood transplantation can decrease the incidence of the severe aGVHD and improve long term survival. It is a safe and effective method of HLA-mismatched hematopoietic stem cell transplantation.关键词
HLA不全相合造血干细胞移植/脐血/血液病Key words
HLA-mismatched hematopoietic stem cell transplantation/ Umbilical Cord Blood/Hematologic diseases分类
医药卫生引用本文复制引用
高力,刘嘉,陈幸华,高蕾,曾韫璟,张诚,张曦..HLA不全相合造血干细胞联合脐血移植治疗急性白血病的临床观察[J].中国输血杂志,2012,25(2):115-119,5.基金项目
国家自然科学基金(81070388)、重庆市自然科学基金重点项目(2009BA5056)、第三军医大学临床科研基金(2010D249、2011D262 （81070388）
