中国输血杂志2012，Vol.25Issue(2)：123-126,4.
人脐带间充质干细胞治疗移植物抗宿主病的临床观察
Observation on humam umbilical cord-mesencnymal Stem Cell for the Treatment of acute graft versus host disease after Hematopoietic Stem Cell Transplantation
摘要
Abstract
Objective To evaluate the efficacy and safety of human umbilical cord mesenchymal Stem Cell (UCMSCs) for the treatment of acute graft versus host disease (aGVHD). Methods Forty patients with aGVHD were divided into two groups. Twenty patients received treatment with tacrolimus, methotrexate and UCMSCs. Twenty patients received treatment with tacrolimus and methotrexate. Results The recovery rate and effective power of UCMSCs-group is higher than the other group (P<0.05). The initial action time of UCMSCs-group and the other group is (16.15 ±6.34)days and(20. 8 ±6. 94)days,respectively (P>0.05). The time to complete remission of UCMSCs-group and the other group is (25.5 ±7.18) d and(30.4 ±8.07)d,respectively(P<0.05). No patient died of infection in UCMSCs-group. There is no adverse reaction during the infusion of UCMSCs. There are two Patients with aGVHD in UCMSCs-group and two in the other group. The recurrence of the disease is never occur in the both groups. Conclusion The infusion of UCMSCs is an effective and safe treatment for aGVHD.关键词
人脐带间充质干细胞/急性移植物抗宿主病/造血干细胞移植Key words
Humam umbilical cord-mesenchymal Stem Cell/ acute graft versus host disease/ Hematopoietic Stem Cell Transplantation分类
医药卫生引用本文复制引用
文钦,彭贤贵,陈幸华,高蕾,张曦,张诚,高力,曾韫璟,孔佩艳,刘红..人脐带间充质干细胞治疗移植物抗宿主病的临床观察[J].中国输血杂志,2012,25(2):123-126,4.基金项目
第三军医大学新桥医院临床科研课题资助项目(2011D262、2010D249) （2011D262、2010D249）
