中国比较医学杂志2012，Vol.22Issue(3)：23-27,31,6.DOI:10.3969/j.issn.1671.7856.2012.03.005
乌司他丁联合血必净对内毒素致绵羊多脏器功能障碍综合征的防治研究
Study on Prevention and Cure of Ulinastatin Combined with XUEBIJING in Multiple Organ Dysfunction Syndrome Induced by Lipopolysaccharide in Sheep
摘要
Abstract
Objective To investigate prevention and cure effect of Ulinastatin( UTI) combined with XUEBUING (XBJ) on multiple organ dysfunction syndrome( MODS) induced by lip polysaccharide (LPS) in sheep . Methods 50 sheep were randomly separated into 5 groups : the control ( Croup A ) , model group ( Group B) , UTI group (Group C ) , XBJ group (Group D) and UTI + XBJ group (Group E) , 10 sheep each group . The MODS model was established by LPS in sheep. It was prevented and cured by UTI, XBJ and UTI + XBJ. Then the physical sign appearance was observed and the indexes of blood gas, blood routine and blood biochemistry were determined in each group. Results The sheep in UTI + XBJ group, the physical sign appearance was obviously alleviative, the death rate was markedly degraded. Arterial oxygen pressure ( PaO2 ) , the biochemical indexes and the number of WBC was regulated efficiently. Conclusion UTI + XBJ could improve obviously physical sign appearance, degrade the death rate and it had favourable preventive and therapeutic effect on damage in multiple organ.关键词
乌司他丁/血必净/多脏器功能障碍综合征/绵羊Key words
Ulinastain/XUEBUING/Multiple organ dysfunction syndrome/Sheep分类
医药卫生引用本文复制引用
牛廷献,万东君,王春雨,陆璐,王红义,罗晓红..乌司他丁联合血必净对内毒素致绵羊多脏器功能障碍综合征的防治研究[J].中国比较医学杂志,2012,22(3):23-27,31,6.基金项目
甘肃省自然科学基金(No.1010RJZA052). （No.1010RJZA052）
