中国比较医学杂志2012，Vol.22Issue(3)：32-35,4.DOI:10.3969/j.issn.1671.7856.2012.003.007
人大肠癌鸡胚尿囊膜移植模型的建立及血管生成特征的观察
Establishment of a Human Colorectal Cancer Model on the Chick Embryo Chorioallantoic Membrane
于文静 1赵静 1连波 2位晓丹 1谢斌 1高志芹3
作者信息
- 1. 潍坊医学院细胞生物学教研室,潍坊261053
- 2. 潍坊医学院生物技术实验室,潍坊261053
- 3. 潍坊医学院药学与生物科学学院,潍坊261053
- 折叠
摘要
Abstract
Objective To establish a human colorectal cancer model on the chick embryo chorioallantoic membrane( CAM ) and study its characteristics of angiogenesis. Methods Human colorectal cancer cell line HT-29 at different concentrations were inoculated on the CAMs. To observe the factors affecting the survival of the transplanted human colorectal cancer, growth characteristics of the transplanting tumor and the characteristics of angiogenesis. Results The transplantation tumor model of human colorectal cancer in CAM was successfully established. It was found that transplantation tumor was easy to grow and it showed strong angiogenesis effects. Conclusions It is feasible to establish a transplantation tumor model of human colorectal cancer on CAM. The model can be easily duplicated, which provides a useful animal model for studying the angiogenesis and biological properties of colorectal cancer and can be used in the research of the drug selection for human colorectal cancer.关键词
大肠癌/鸡胚尿囊膜/模型,动物/血管生成Key words
Colorectal cancer/Chicken embryo choriallantoic membrane/Model, animal/Angiogenesis分类
医药卫生引用本文复制引用
于文静,赵静,连波,位晓丹,谢斌,高志芹..人大肠癌鸡胚尿囊膜移植模型的建立及血管生成特征的观察[J].中国比较医学杂志,2012,22(3):32-35,4.
