中国比较医学杂志2012，Vol.22Issue(3)：45-49,55,6.DOI:10.3969/j.issn.1671.7856.2012.003.010
转基因鼠在脑缺血氧化应激研究中的应用
Application of Transgenic Mice to Studies on Oxidative Stress Mechanism of Cerebral Ischemia
王译晗 1张霞 1张婷慧 1张予阳1
作者信息
- 1. 沈阳药科大学生命科学与生物制药学院,沈阳110016
- 折叠
摘要
Abstract
Reactive oxygen species are important factors, which directly or indirectly involve in the process of cerebral ischemia and reperfusion injury. They are not only regulated by the balance between prooxidant and antioxidant enzymes in brain,but also participate in the various molecular signal pathway in cells. Therefore,they play an important role in the course of neuronal death events. In recent years, transgenic and gene-knockout mice have been widely used in research of the enzymes which influence the formation and elimination of reactive oxygen species, And they also are utilized in the study of the proteins which mediate a variety of cell death and apoptosisl. The animals provide necessary conditions for researchers to conduct the foundamental and applied studies on treatment of cerebral ischemia or reperfusion injury.关键词
转基因鼠/脑缺血/氧化应激Key words
Transgenic mice/Cerebral ischemia/Oxidative stress分类
医药卫生引用本文复制引用
王译晗,张霞,张婷慧,张予阳..转基因鼠在脑缺血氧化应激研究中的应用[J].中国比较医学杂志,2012,22(3):45-49,55,6.
