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HIV超感染防御研究进展

熊竞 丛喆 魏强

中国比较医学杂志2012,Vol.22Issue(3):61-64,4.
中国比较医学杂志2012,Vol.22Issue(3):61-64,4.DOI:10.3969/j.issn.1671.7856.2012.003.013

HIV超感染防御研究进展

Introduction to the Superinfection with HIV Infection

熊竞 1丛喆 1魏强1

作者信息

  • 1. 中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京 100021
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摘要

Abstract

The retroviral phenomenon of superinfection resistance defines an interference mechanism that is established after primary infection, and provides possible protection against the challenge with the same virus. A better knowledge of superinfection resistance-induced mechanisms could be useful for the development of an HIV vaccine or other antiviral strategies. Present studies suggest that the SIR based on infected cells and the immune response in vivo were concluded to be the main possible reasons for the protection against superinfection. However, so far the real mechanism in protecting patients from HIV superinfection has not been studied throughly. This paper reviews the findings and introduces the updates of superinfection with HIV infection.

关键词

HIV/超感染抵抗(SIR)/CD4下调

Key words

HIV/Superinfection resistance/SIR/CD4 downregulation

分类

医药卫生

引用本文复制引用

熊竞,丛喆,魏强..HIV超感染防御研究进展[J].中国比较医学杂志,2012,22(3):61-64,4.

基金项目

国家十二五科技重大专项课题(2012ZX10004-501,2012ZX10001-006). (2012ZX10004-501,2012ZX10001-006)

中国比较医学杂志

OACSTPCD

1671-7856

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