摘要
Abstract
Objective To investigate the present situation of pediatric purulent meningitis, including risk factors, clinical manifastation, diagnosis, treatment, and prognosis in order to provide information for definitive diagnosis and better treatment. Methods All the clinical and laboratory data of 66 cases of pediatric purulent meningitis, who were admitted to Neurology Department of Children's Hospital of Fudan University from January 2008 to April 2010, were collected , analysed, compared and summarized. The average age of all the patients was 6 months (from 30 days to 11 years), including 47 infants(71.2%), 11 toddlers(16.7%),5 pre-school children (7.6%) and 3 school age cases (4.5%). Results Most cases in pre-school and school age had risk factors. According to the levels of our diagnosis, 33.3% got definite pathogen diagnosis, 50.0% got clinical diagnosis, and 16.7% got suspicious diagnosis. The positive rate of initial CSF(cerebral spinal fluid) was 62.5%, much higher than that of CSF in patients treated with antibiotics (29.8% ). The rate of abnormal high count of WBC in two different kinds of CSF had significant difference (P = 0.03) .while there were no difference in the levels of glucose and protein of CSF. In the 66 cases, 80.3% got well or improved, while 19.7% gave up. The course of treatment averaged 21 days (5 to 56days),which had no difference between cases with 3 diagnosis levels. Some cases had complications, including subdural effusion, dysaudia.hydrocephalus and subdural empyema. Conclusion Purulent meningitis continues to be an severe and emergent disease in neonates and children.Diagnosis with different standards according to clinical manifestation helps the management of pediatric purulent meningitis cases.关键词
儿童/化脓性脑膜炎/易感因素/病原学诊断/脑脊液Key words
children/purulent meningitis/risk factor/pathogen diagnosis/cerebral spinal fluid分类
医药卫生
