中国兽医科学2012，Vol.42Issue(1)：13-18,6.
MHC B-L基因多态性与鸡白痢沙门氏菌易感性的关联分析
Association of MHC B-L gene polymorphism with susceptibility of Salmonella pullorum
摘要
Abstract
To study the association between MHC B-L gene polymorphism and Salmonella pullorum infection,polymerase chain reaction sequence-based typing method was used to detect the polymorphism of MHC B-L gene exon 2. The Plinkl. 07 and PHASE V2. 1 software was used as case-control association study and haplotype analysis, respectively. There were 42 single nucleotide polymorphisms（SNPs） in 270 bp DNA sequence. The distribution of C. 280C〉A alleles had a significant difference in case-control samples. The distribution of C. 246G〉T and C. 249A〉G genotypes had a significant difference in case-control samples. Haplotypes within the C. 229T〉A and C. 249A〉G sites and within the C. 285G〉A,C. 287A〉T and C. 288C〉A sites did not associate with anti-pullorum disease trait. The results showed that the polymorphism of MHC B-L gene exon 2 was significant associated with anti-pullorum disease trait, and provided some bases for developing marker assisted selection programmes for anti-salmonellosis.关键词
鸡白痢/易感性/MHC/B-L/单核苷酸多态性位点/单倍型Key words
pullorum/susceptibility/MHC B-L/SNPs/haplotype分类
农业科技引用本文复制引用
张泽樘,龚超,陈卓宇,张细权,罗庆斌..MHC B-L基因多态性与鸡白痢沙门氏菌易感性的关联分析[J].中国兽医科学,2012,42(1):13-18,6.基金项目
国家肉鸡产业技术体系项目(CARS-42-G05) （CARS-42-G05）
国家高技术研究发展计划(863)项目(2011AA10030) （863）
