中国兽医科学2012，Vol.42Issue(1)：83-87,5.
猪脾转移因子微囊的制备及其活性检测
Preparation and bioactivity of pig spleen transfer factor microcapsules
摘要
Abstract
To enhance the stability of transfer factor,pig spleen transfer factor microcapsules were prepared by emulsion external gelatification method in an emulsion system with chitosan and sodium alginate. Diameter size,loading rate,and encapsulation efficiency of the microcapsules were detected. And the pharmacological bioactivity of the microcapsules in mice was examined by phagocytosis Of macrophage and delayed hypersensitivity. The pig spleen transfer factor microcapsules were showed sphere-like, the average diameter was 11.05μm,the loading rate was 11.60 mg/g,and the encapsulation efficiency was 60.8%. The transfer factor microcapsules could potentiate the macrophage phagocytic function,enforce the delayed hypersensitive response. The results indicated that the transfer factor microcapsules had a better therapeutic effect than transfer factor. In conclusion, the preparation procedure is simple and the transfer factor microcapsules possess excellent development and application prospects.关键词
转移因子/壳聚糖-海藻酸钠微囊/乳化外部凝胶法/巨噬细胞吞噬试验/迟发型超敏反应Key words
transfer factor/chitosan/alginate microcapsules/emulsion external gelatification/phagocytosis of macrophage/delayed hypersensitivity分类
农业科技引用本文复制引用
符华林,唐文,黄平全,金超,胡俊,邓凤英..猪脾转移因子微囊的制备及其活性检测[J].中国兽医科学,2012,42(1):83-87,5.基金项目
教育部"长江学者和创新团队发展计划"创新团队项目(IRT0848) （IRT0848）
