中国兽医科学2012，Vol.42Issue(4)：394-400,7.
ELISA抗体水平评价口蹄疫灭活疫苗免疫效果的可行性分析
Feasibility study of the effect of foot-and-mouth disease inactivated vaccine by antibody titer evaluation
摘要
Abstract
In order to evaluate the feasibility of foot-and-mouth disease vaccine according to antibody level,five batches of inactivated vaccine against foot-and-mouth disease（FMD） type O Asia 1 and five batches of inactivated vaccine against swine FMD type O were inoculated to the animals.While the relationship between antibody titers and immune protection percentages was evaluated by liquid blocking ELISA.The statistical data proved that the O antibody titer of the inactivated vaccine against FMD type O Asia 1 was positively correlated with the protection percentages（probability units） post-challenge（P0.01,r=0.986）.Asia 1 antibody titer of the inactivated vaccine against FMD type O Asia 1 was positively correlated（P0.05,r=0.997） with the percentages of protection（probability units） post-challenge,but O antibody titers of the inactivated vaccine against swine FMD type O were not positive correlated（P0.05） with the percentage of protection（probability units） post-challenge.The result indicated that it is entirely feasible to evaluation of effectiveness of the inactivated vaccine against FMD type O Asia 1 using antibody titers,and not feasible to evaluation of effectiveness of the inactivated vaccine against FMD type O swine using antibody titers.关键词
口蹄疫/灭活疫苗/抗体水平/百分率/免疫效果Key words
foot-and-mouth disease/inactivated vaccine/antibody level/immunization effectiveness分类
农业科技引用本文复制引用
施程洪,刘绍阳,朱明旺,王继华,代保坤,赵文祥,彭正啟..ELISA抗体水平评价口蹄疫灭活疫苗免疫效果的可行性分析[J].中国兽医科学,2012,42(4):394-400,7.基金项目
中牧实业股份有限公司2010年技改项目 （）
