中国实用内科杂志2012，Vol.32Issue(3)：198-200,3.
不同症状评估方式对胃食管反流病诊断价值比较研究
Comparison of various approaches for symptom assessment of gastroesophageal reflux disease
徐定婷 1冯桂建 1赵丽莉 1刘玉兰1
作者信息
- 1. 北京大学人民医院消化科,北京100044
- 折叠
摘要
Abstract
Objective To compare the diagnostic value of various approaches for assessment of reflux diseases in patients with gastroesophageal reflux disease ( GERD). Methods We enrolled 300 patients with confirmed or suspected diagnosis of GERD from the department of gastroenterology, People's Hospital of Peking University between March 2007 and December 2010. All patients completed reflux disease questionnaire ( RDQ) ,and underwent gastroscopy and esophageal dynamic pH monitoring. The variation in conventional questionnaire score, Montreal definition score and the sum of frequency-severity product of each symptom were compared. Results Montreal definition was shown as having the highest (67.4% ) sensitivity,while specificity ranked top (61. 2% ) for accumulated score of frequency-severity product of each symptom. Youden index reached to a peak when RDQ total score ≥14. The disparity among three approaches was unremarkable,as suggested by Kappa's test. A negative predictive value of 75.4% for esophagitis was obtained using RDQ ≥12 as positive criterion. In addition to more accumulated, postprandial and postprandial long-term reflux episodes, subjects with positive results had higher proportion of orthostatic and total duration with PH ＜4,increased DeMeester score and index of reflux area ( all P ＜ 0.05). RDQ was positively correlated with the number of accumulated and postprandial reflux episodes,the proportion of orthostatic and total duration with PH ＜4 as well as the index of reflux area. Conclusion Different questionnaire assessments do not vary statistically. Symptom questionnaire is of higher predictive significance to reflux esophagitis, while RDQ total score is positively correlated with the parameters in terms of PH monitoring.关键词
胃食管反流病/反流性疾病问卷/蒙特利尔定义Key words
GERD/reflux disease questionnaire/the Montreal Definition分类
医药卫生引用本文复制引用
徐定婷,冯桂建,赵丽莉,刘玉兰..不同症状评估方式对胃食管反流病诊断价值比较研究[J].中国实用内科杂志,2012,32(3):198-200,3.
