摘要
Abstract
Objective To evaluate the diagnostic value of plasma 1,3-p-D glucan ( BG ) assay ( G test) to invasive fungal infection( IFI) in children. Methods By retrospectively accessing the clinical data of pediatric inpatients who underwent G test and the patients were recruited from January 2008 to August 2011. According to the diagnosis standard of IFI, children were divided into IFI group and non-IFI group. G test was performed by the GKT-5M Set Kinetic Fungus Detection Kit. It was judged as positive when the plasma BG level≥10 pg· mL-1. 2 by 2 table was used to calculate the G test for the diagnosis of IFI sensitivity, specificity, positive predictive value and negative predictive values. Receiver operating curve ( ROC ) of G test was analyzed, and the area under the curve was calculated. Results A total of 525 inpatients received G test, 129 of them with suspected IFI diagnosis were excluded. Forty-three patients were diagnosed as IFI ( 9 as proven, 34 as probable ), and 353 without IFI. In IFI group G test was positive in 31/43 cases, the positive rate was 72. 1% ; negative in 12/43 cases, false negative rate was 27. 9%. 48/353 cases of non-IFI group were positive, false positive rate was 13. 6%. The sensitivity, specificity, positive and negative predictive values were 72. 1%, 86.4%, 39.2% and 96. 2% respectively. According to ROC analysis, the AUC was 0. 815( 95% CI:0.732 -0. 898 ). Conclusions G test has good diagnostic value of IFI in children. Appropriately higher cutoffs or continuous monitoring may significantly control false positive rate of the test.关键词
儿童/侵袭性真菌感染/1,3-β-D葡聚糖/诊断Key words
Children/Invasive fungal infection/1 ,3-β-D glucan/Diagnosis
