摘要
Abstract
OBJECTIVE: To observe the analgesic effects of ketorolac tromethamine and pethidine hydrochloride in the treatment towards renal colic. METHODS: 120 presenting moderate and severe pain of renal colic patients who were received and treated by our hospital during the May 2008 to May 2010. The qualified cases were randomly divided into 3 groups, 40 cases each and given intramuscular injection: Group I , ketorolac tromethamine 60 mg; Group Ⅱ , pethidine hydrochloride 100 mg; Group Ⅲ , ketorolac tromethamine 30 mg +pethidine hydrochloride 50 mg. Pain intensity (PI) , pain intensity difference (PID) , pain relief (PAR) and adverse reaction were recorded by the observer before and within 3 h (0, 0.5, 1, 1.5, 2, 2.5, 3 h) of using the drug in order to evaluate the analgesic effect. RESULTS: 3 groups were all onset of analgesia 0.5 h after the injection. In terms of moderate pain, Group Ⅲ showed a better improvement for all observation points within 3 h than Group Ⅰ , Ⅱ (P＜0.05), and more significantly at 2 h (P＜0.01). In terms of severe pain. Group Ⅲ showed a better improvement than Group I , II at the point of 1.5, 2, 2.5, 3 h with statistically significant difference (P＜0.05). Despite the point 0.5 h, there was a statistically significant differences between Group Ⅲ and Group Ⅰ , Ⅱ on the degree of moderate relief (P＜0.05). The incidence of adverse reactions of Group Ⅲ was less than the other 2 groups(P＜0.05). CONCLUSIONS: The combination mode of ketorolac tromethamine and pethidine hydrochloride performed a remarkable effects, better than the 2 drugs used alone. The combination mode not only reduced the dose of pethidine hydrochloride ,but also extended duration of analgesia, which was an effective treatment of renal colic with good safty.关键词
酮咯酸氨丁三醇/盐酸哌替啶/肾绞痛/镇痛Key words
Ketorolac tromethamine/ Pethidine hydrochloride/ Renal colic/ Analgesia分类
医药卫生
