中国药房2012，Vol.23Issue(13)：1174-1176,3.DOI:10.6039/j.issn.1001-0408.2012.13.08
雌激素和雷洛昔芬对骨质疏松症模型大鼠胫骨干骺端骨折愈合的影响研究
Effects of Estrogen and Raloxifene on Tibia Metaphyseal Fracture Healing of Osteoporosis Model Rats
路坦 1董玉珍 1徐海斌1
作者信息
- 1. 新乡医学院第一附属医院骨科,河南卫辉453100
- 折叠
摘要
Abstract
OBJECTIVE: To investigate the effects of estrogen and raloxifene on tibia metaphyseal fracture healing of ovariotomy model rats. METHODS: Female rats were randomly divided into normal control group, model group, sham operation group, estradiol benzoate group (0.5 mg-d"') and raloxifene group (3.4 mg-d"1). Except for normal control group, those groups received ovariotomy to establish osteoporosis model while sham operation group received sham operation. In case of same anaesthesia, rats were given tibia metaphyseal osteotomy and internal fixation, 10 rats in each group. After operation, rats were fed with spud protein and relevant drugs 20 g. Biomechanical tests (rigidity as index), histomorphology analysis (poroma area and density, trabecu-la node number as index) and total poroma area of tibia in each group were conducted 5 weeks later. RESULTS: Compared with normal control group, model group and sham operation group, rigidity of tibia, poroma area and density, trabecula node number and total poroma area increased significantly in estradiol benzoate group and raloxifene group (P<0.05). CONCLUSION: Raloxifene can replace estrogen for improving tibia metaphyseal fracture healing of osteoporosis model rats.关键词
骨质疏松症/大鼠/雷洛昔芬/苯甲酸雌二醇/干骺端骨折愈合Key words
Osteoporosis/Rats/Raloxifene/Estradiol benzoate/Metaphyseal fracture healing分类
医药卫生引用本文复制引用
路坦,董玉珍,徐海斌..雌激素和雷洛昔芬对骨质疏松症模型大鼠胫骨干骺端骨折愈合的影响研究[J].中国药房,2012,23(13):1174-1176,3.
