中国药房2012，Vol.23Issue(13)：1210-1212,3.DOI:10.6039/j.issn.1001-0408.2012.13.21
盐酸莫西沙星静电纺丝膜的制备及性能研究
Study on Preparation and Properties of Moxifloxacin Hydrochloride Electrostatic Spinning Membrane
谢红 1黄华 2卢华 3卢来春 1管海燕1
作者信息
- 1. 第三军医大学大坪医院野战外科研究所药剂科,重庆400042
- 2. 重庆医科大学药学院药剂学教研室,重庆400016
- 3. 即墨市中医院妇产科,山东即墨266000
- 折叠
摘要
Abstract
OBJECTIVE: To prepare Moxifloxacin (MH) electrostatic spinning membrane with antibacterial action. METHODS : Electrostatic spinning membrane with good permeability property was prepared using PVA and SA as carrier and MH as model drug. Spinning solution with various volume ratios of 12% PVA to 2% SA (4 : 1, 3.5 : 1.5, 3:2, 2.5 : 2.5, 2:3, 1:4) and drug-loading amount were screened to determine the optimal formulation using spinnability of solution and electrostatic spinning morphology as index. Electrostatic spinning membrane was determined, and permeability property of it was compared with non-woven cloth cover. RESULTS: The optimal formulation was as follows: volume ratio of 12% PVA to 2% SA was 3:2, drug-loading amount was 2%. Spinning solution showed sound spinnability, and the prepared electrostatic spinning had small and uniform diameter, smooth surface and small amounts of beaded spinning. The yield of it was (86.73 ± 2.92) % , and permeability property of electrostatic spinning membrane was better than that of non-woven cloth (P<0.05). CONCLUSION: Prepared MH electrostatic spinning membrane loads drug uniformly and has good permeability.关键词
盐酸莫西沙星/聚乙烯醇/海藻酸钠/静电纺丝膜/透气性能Key words
Moxifloxacin hydrochloride/Polyvinyl alcohol/Sodium alginate/Electrostatic spinning membrane/Permeability分类
医药卫生引用本文复制引用
谢红,黄华,卢华,卢来春,管海燕..盐酸莫西沙星静电纺丝膜的制备及性能研究[J].中国药房,2012,23(13):1210-1212,3.
