中国药房2012，Vol.23Issue(13)：1215-1217,3.DOI:10.6039/j.issn.1001-0408.2012.13.23
RP-HPLC双波长法同时测定西替伪麻缓释片中2组分含量
Simultaneous Determination of Two Compounds in Cetirizine/Pseudoephedrine Sustained-release Tablets by Dual-wavelength RP-HPLC
摘要
Abstract
OBJECTIVE: To establish a method to determine the contents of pseudoephednne hydrochlonde (,PEH) and cetm-zine hydrochloride (CTH) in Cetirizine/pseudoephedrine sustained-release tablets simultaneously. METHODS: Dual-wavelength RP-HPLC method was adopted. Diamonsil? Cis column was used with acetonitrilel-0.02 mol-L^1 water solution of sodium acetate-perchloric acid-triethylamine (40 : 60 : 0.5 : 0.1, pH adjusted to 5.2 ± 0.2) at the flow rate of 1 mL? Min-1. The detection wavelengths were set at 257 nm for PEH and 230 ran for CTH. RESULTS: The linear ranges were 0.05-0.3 mg-mL"1 for PEH (r= 0.999 9) and 4-14 ug·mL-1 for CTH 0=0.999 8). Recovery rates of low, middle and high concentrations were 98.8% , 98.6% and 99.2% for PEH (RSD<0.61%) and 100.2%, 98.9% and 99.3% for CTH (RSD<1.06%), respectively. CONCLUSION: The method is simple, accurate and reproducible, and can be used for the content determination of two compounds in Cetirizine/ pseudoephednne sustained-release tablets.关键词
西替伪麻缓释片/盐酸西替利嗪/盐酸伪麻黄碱/含量测定/反相高效液相色谱法/双波长Key words
Cetirizine/pseudoephedrine sustained-release tablets/Cetirizine hydrochloride/Pseudoephednne hydrochloride/Content determination/RP-HPLC/Dual-wavelength分类
医药卫生引用本文复制引用
谢清春,吕竹芬,陈燕忠..RP-HPLC双波长法同时测定西替伪麻缓释片中2组分含量[J].中国药房,2012,23(13):1215-1217,3.基金项目
广东省中国科学院全面战略合作项目(2010B090301043) （2010B090301043）
