中国药房2012，Vol.23Issue(15)：1354-1355,2.DOI:10.6039/j.issn.1001-0408.2012.15.04
槐白皮水提物对60Co-γ射线损伤小鼠脾细胞的免疫保护作用研究
Study on the Immune Protective Effect of Sophora japonical Water Extract on the Spleen Cells of 60Co-γ Ray Irradiated Injured Mice
摘要
Abstract
OBJECTIVE: To evaluate the immune protective effect of Sophora japonical water extract on the spleen cells of 6cCo-y ray irradiated injured mice. METHODS: Mice were randomly divided into 5 groups: normal group (constant volume normal saline), irradiation control group (constant volume normal saline) ,S. Japonical water extract high-dose, medium-dose and low-dose groups(0.8, 0.4, and 0.2 mL?kg"'). All the mice were irradiated with Mco-y ray except normal group, and then S. Japonical water extract was given once a day for 10 days. And then nitric oxide (NO) level and spleen index was detected in spleen cell of mice. RESULTS: NO level of S. Japonical water extract medium-dose group was significantly lower than irradiation control group(P< 0.01), and the spleen index of S. Japonical water extract medium-doce group and low-dose groups was significantly higher than irradiation control group(f <0.01 or P<0.05). CONCLUSIONS: S. Japonical water extract can reduce the damage of the irradiated spleen cells, and have the immune protective function.关键词
槐白皮/一氧化氮/脾指数/放射损伤Key words
Sophora japonical/ NO/ Spleen index/ Irradiation injury分类
医药卫生引用本文复制引用
张跃进,董海艳,张婵,李安乐,陈向敏..槐白皮水提物对60Co-γ射线损伤小鼠脾细胞的免疫保护作用研究[J].中国药房,2012,23(15):1354-1355,2.基金项目
浙江省教育厅科研计划项目(20030800) （20030800）
