中国药房2012，Vol.23Issue(15)：1361-1363,3.DOI:10.6039/j.issn.1001-0408.2012.15.07
汉防己甲素聚乳酸微球的安全性评价
Safety Evaluation of Tetrandrine Polylactic Acid Microspheres
摘要
Abstract
OBJECTIVE: To evaluate the safety of Polylactic acid microspheres (TET-MC). METHODS: The in-liquid drying was used to prepare TET-MC. The acute toxicity LD? Test, venous and muscular stimulation test, allergic test in vitro were conducted. RESULTS: The value of LD? For mice with intravenous injection was 158.9 mg-kg"1. There was slight muscle stimulating, but no veins stimulating, allergic reactions. CONCLUSION: Toxicity of TET is decreased by microsphere and TET-MC is basically safe.关键词
汉防己甲素/微球/急性毒性/安全性Key words
Tetrandrin/ Microspheres/ Acute toxicity/ Safety分类
医药卫生引用本文复制引用
胡泽丽,程国华,庞廷媛,陈娟,汪小乐..汉防己甲素聚乳酸微球的安全性评价[J].中国药房,2012,23(15):1361-1363,3.基金项目
广州市科技三项项目(2006Z3-E4121) （2006Z3-E4121）
