中国药房2012，Vol.23Issue(15)：1375-1377,3.DOI:10.6039/j.issn.1001-0408.2012.15.12
葛根素自微乳制剂的制备工艺研究
Study on the Preparation Technology of Puerarin Self-microemulsfying Delivery System
摘要
Abstract
OBJECTIVE: To study on the preparation of Puerarin self-microemulsifying drug delivery system (SMEDDS). METHODS: The oil phase, emulsifier and auxiliary emulsifier were selected according to the saturation solubility of puerarin. The optimal formulation was determined by pseudo-ternary phase diagram using self-emulsifying efficiency and the emulsion particle size as the index. RESULTS: The optimal formulation was ethyl oleate:Tween-80/EL-40 (1:2):PEG 400:puerarin:PNS= 15:35 = 35:6 :9. The average diameter was 32.9 nm. CONCLUSION: Puerarin SMEDDS added into Panax pseudoginseng total saponins has small particle size and sound stability, which provides new idea and channel for efficacy-increasing and toxicity-reducing of SMEDDS prepration.关键词
葛根素/自微乳给药系统/三七总皂苷/伪三元相图/减毒增效Key words
Puerarin/ Self-microemulsifying drug delivery system/ Panax pseudoginseng total saponins/ Pseudo-ternary phase diagram/ Efficacy-increasing and toxicity-reducin分类
医药卫生引用本文复制引用
杨文莲,牛涛,傅春升,张红艳,孙洪胜..葛根素自微乳制剂的制备工艺研究[J].中国药房,2012,23(15):1375-1377,3.基金项目
山东省中医药科技发展计划项目(2009-086) （2009-086）
