中国药房2012，Vol.23Issue(15)：1378-1379,2.DOI:10.6039/j.issn.1001-0408.2012.15.13
正交试验优选姜黄素明胶微球的处方工艺
Optimization of the Formulation Technology of Curcumin Gelatin Microspheres by Orthogonal Test
摘要
Abstract
OBJECTIVE: To study the best preparation technology of Curcumin gelatin microspheres. METHODS: Emulsion chemical cross-linking method for the preparation of Curcumin gelatin microspheres was optimized by orthogonal experiment using gelatin concentration, oil/water ratio and emulsification time as factors with drug-loading amount, encapsulation coefRcency and particle size as index using gelatin as carrier. RESULTS: The optimal formulation technology of Curcumin gelatin microspheres was as follows: the ratio of water to oil was 1 = 5, the concentration of gelatin was 25% and the emulsification time was 30 tnin. CONCLUSION: The formulation technology is stable, feasible and reproducible, and it provides theoretic basis for the further study of Curcumin gelatin microspheres.关键词
姜黄素/明胶/微球/肺靶向Key words
Curcumin/ Gelatin/ Microspheres/ Lung-targeting分类
医药卫生引用本文复制引用
邓航,陈薇,黄桂红,李江,邓俊刚..正交试验优选姜黄素明胶微球的处方工艺[J].中国药房,2012,23(15):1378-1379,2.基金项目
广西科学研究与技术开发计划项目(桂科攻0999003) （桂科攻0999003）
广西医疗卫生重点科研课题(重2010054) （重2010054）
