中国药房2012，Vol.23Issue(15)：1411-1413,3.DOI:10.6039/j.issn.1001-0408.2012.15.27
3种方法制备的胃肠复原汤中黄芪甲苷含量的比较
Comparison of the Content of Astragaloside Ⅳ in Weichang Fuyuan Decoction Prepared by 3 Kinds of Methods
许保海 1臧琛 2张宏伟 1潘旭 1魏娜 1聂其霞2
作者信息
- 1. 北京积水潭医院,北京100035
- 2. 中国中医科学院中药研究所,北京 100700
- 折叠
摘要
Abstract
OBJECTIVE: To determine the content of astragaloside IV in Weichang fuyuan decoction prepared by 3 kinds of methods (traditional single dose decoction method, decoction machine multiple decoction method, magistral granule dissolution method). METHODS: HPLC method was adopted. The determination was performed on Kromasil Cu(150 mm><4.6 mm,5 |im)column with mobile phase consisted of acetonitrile-water (31:69) at the flow rate of 1.0 mL-mitT'. Alltech 2000ES evaporative light scattering detector was adopted with drift tube of 105 X. And flow rate of 2.0 mL-min"1. RESULTS: The linear range of astragaloside IV was 0.483 2~1.449 6 ug(r=0.999 3) with an average recovery of 97.21% (RSD=1.45%,?=6). The average content of 3 batches of traditional Weichang fuyuan decoction was 0.225 0 mg-g"1, that of 3 batches of decoction prepared by machine was 0.154 5 mg-g"' and that of 3 batches of magistral granule was 0.274 2 mg?g~'. CONCLUSION: The content of astragaloside IV in Weichang fuyuan decoction of magistral granule is slightly higher than traditional decoction, and they are much higher than decoction prepared by machine. The difference of batches of magistral granule is similar to that of traditional decoction, but decoction prepared by machine has great difference.关键词
胃肠复原汤/传统单剂煎煮/煎药机多剂煎煮/配方颗粒/黄芪甲苷Key words
Weichang fuyuan decoction/ Traditional single dose decoction/ Decoction machine multiple decoction/ Magistral granule/ Astragaloside IV分类
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许保海,臧琛,张宏伟,潘旭,魏娜,聂其霞..3种方法制备的胃肠复原汤中黄芪甲苷含量的比较[J].中国药房,2012,23(15):1411-1413,3.
