中国药房2012，Vol.23Issue(21)：1947-1948,2.DOI:10.6039/j.issn.1001-0408.2012.21.11
纳米银溶液及其凝胶的体外抗菌作用研究
Study on the in Vitro Antibacterial Effects of Silver Nanoparticle Solution and Silver Nanoparticle Gel
摘要
Abstract
OBJECTIVE: To investigate the in vitro antibacterial effects of silver nanoparticle solution and silver nanoparticle gel in order to provide theoretical basis for external application of silver nanoparticles for anti-infection of burn and scald. METHODS: Using sulfadiazine silver as positive control, the minimum inhibitory concentrations of silver nanoparticles solution and silver nanoparticle gel to Pseudomonas aenigmosa, Staphyhcoccus aureus, Escherichia coli, Bacillus proteus, Serratia marcescens, Pseudomonas spec, Staphylococcus epidermidis, Enterococcus, Klebsiella pnewnoniae, Candida albicans were determined by tube double dilution method. RESULTS: The minimum inhibitory concentrations of silver nanoparticle solution, silver nanoparticle gel and sulfadiazine silver to above 10 bacterials were 2.5-10 μg·mL-1, 4~32 μg·mL-1, 32~64 μg·mL-1. Antibacterial effects of silver nanoparticles solution and silver nanoparticle gel were better than sulfadiazine silver. CONCLUSION: The two forms of silver nanoparticles have broad antibacterial spectrum and strong antibacterial activity in vitro, which provide theoretical basis for external application of silver nanoparticles for anti-infection of burn and scald.关键词
纳米银溶液/纳米银凝胶/抗茵作用/试管二倍稀释法Key words
Silver nanoparticle solution/ Silver nanoparticle gel/ Antibacterial effects/ Tube double dilution method分类
医药卫生引用本文复制引用
李明春,马守栋,曹恩惠,赵丽艳,叶勇..纳米银溶液及其凝胶的体外抗菌作用研究[J].中国药房,2012,23(21):1947-1948,2.基金项目
国家"重大新药创制"科技重大专项资助项目(2008ZXJ09004-045) （2008ZXJ09004-045）
