中国医科大学学报2012，Vol.41Issue(1)：1-4,4.
创伤后应激障碍大鼠动眼神经核神经元5-羟色胺1A受体表达的变化
The Expression of 5-HT1A Receptor in the Oculomotor Nucleus of Posttraumatic Stress Disorder Rats
摘要
Abstract
Objective To observe the change of 5-HT1A receptor-expression in the oculomotor nucleus of posttraumatic stress disorder rats. Methods The SPS-method was used to set up the rat FTSD models. Rats were randomly divided into 1 d,4 d and 7 d groups of single prolong stress (SI'S) and a normal group. Immunohistochemical and Western blot were used to detect the expression of 5-HT1A receptor in the oculomotor nucleus. The change of ultrastructure in the neuron were objected by transmission electron microscopy (TEM). Results The expression of 5-HT1A receptor in the oculomotor nucleus neurons gradually increased on 1 d,4 d and 7 d after exposure to SPS than that of the control group,and reached the peak level at 7 d after SPS exposure. There was also a change of ultrastructure in the oculomotor nucleus neuron detected. Conclusion SPS exposure resulted in the change of 5-HT1A receptor expression in the oculomotor nucleus,which might be related to the pathogenesis of PTSD.关键词
创伤后应激障碍/动眼神经核/5-羟色胺1A受体/神经元/免疫组化Key words
posttraumatic stress disorder/ oculomotor nucleus/ 5-HT1A receptor/ neuron/ immunohistochemistry分类
医药卫生引用本文复制引用
刘冬娟,韩芳,肖冰,罗斐斐,徐盟,王恩华,石玉秀..创伤后应激障碍大鼠动眼神经核神经元5-羟色胺1A受体表达的变化[J].中国医科大学学报,2012,41(1):1-4,4.基金项目
国家自然科学基金资助项目(31140060,81171282) （31140060,81171282）
教育部博士点基金资助项目(20092104110016) （20092104110016）
