中国医科大学学报2012，Vol.41Issue(1)：28-30,41,4.
白藜芦醇对帕金森病大鼠黑质多巴胺能神经元损伤的保护作用
The Study on the Neuroprotective Effects of Resveratrol against Degeneration of Dopaminergic Neurons in Parkinson's Disease Rat Model
摘要
Abstract
Objective To observe the neuroprotective effects of resveratrol (Res) against degeneration of dopaminergic neurons which caused by LPS in vivo. Methods PD rat model were made by intranigral injection of LPS. Sprague-Dawley rats were randomly divided into control group,PD group and Res group. Behaviour study,tyrosine hydroxylase(TH) and nuclear factor kappa B( NF-κB ),immuno-histo-chemistry and Western blot were performed. Results The control group showed no rotational behavior, the number of circling behavior in PD group was the most in all groups (196.90±9.52). There was significant differences compared with control group and Res group (P < 0.01 ).The number of TH positive cells and the expression of TH protein in substantial nigra of PD group significantly decreased compared with control group (P < 0.01);the NF-κB positive cells and NF-kB protein expression were upregulated and showed the most of microglias activation. But compared with PD group, the number of TH positive cells and TH protein expression was increased,the NF-κB positive cells and NF-kB protein expression was decreased in Res group (P < 0.01). Conclusion Res snowed neuroprotective effects against the degeneration of dopaminergic neurons caused by LPS in vivo.关键词
白藜芦醇/多巴胺能神经元/脂多糖Key words
resveratrol/ dopaminergic neuron/ lipoporysaccharide分类
医药卫生引用本文复制引用
王聪杰,牛平,陈鑫,刘宝茹,辛志强..白藜芦醇对帕金森病大鼠黑质多巴胺能神经元损伤的保护作用[J].中国医科大学学报,2012,41(1):28-30,41,4.基金项目
辽宁省自然科学基金资助项目(20052072) （20052072）
