中国医科大学学报2012，Vol.41Issue(1)：52-55,58,5.
乙酰肝素酶与GA结合蛋白α在乳腺癌组织中的表达及意义
The Expression and Significance of Heparanase and GABPα in Breast Cancer
王巧欢 1张文竹 1宦大为 1杨波 2张弘1
作者信息
- 1. 中国医科大学基础医学院病理解剖学教研室,沈阳110001
- 2. 沈阳军区总医院肝胆外科,沈阳110015
- 折叠
摘要
Abstract
Objective To analyze the dinicopathological significance of hepaianase(HPA) and GA-binding protein a (GABPα) in normal mammary glands and invasive ductal carcinoma (IDC) and to discuss the role and correlation between them during breast carcinogenesis. Methods HPA and GABPa expression were examined by immuneohistochemistry.and the relationship between the HPA and GABPa protein expression and the clinical pathologic features were analyzed. Western blot analysis was conducted to determine the HPA and GABPa expression. Results Immunohistochemistry showed that heparanase and GABPa were distributed in cytoplasm and nuclear of tumor cells,in contrast to their nonexpression in normal breast tissue. GABP-positive cases and HPA-positive cases had a higher positive rate in breast cancer than that of normal breast tissues (P < 0.05 ).As well as in western blot. The expressions of them were related to histological grade,TNM staging and lymph node metastasis. ( P < 0.05 ). And the expression of them were positively correlated in breast cancer (P < 0.05 ). Con-dusioa Our results indicated that both SIAH2 and Bcl-2 are involved in breast cancer and might imply coordination in breast tumorigene-sis.关键词
乙酰肝素酶/GA结合蛋白α/乳腺癌/Western blot/免疫组织化学Key words
heparanase/ GA-binding protein a/ breast cancer/ Western blot/ immunohistochemistry分类
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王巧欢,张文竹,宦大为,杨波,张弘..乙酰肝素酶与GA结合蛋白α在乳腺癌组织中的表达及意义[J].中国医科大学学报,2012,41(1):52-55,58,5.
