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缺氧复氧对乳鼠心肌细胞的损伤的研究

侯志文 于波 孟凡吉 孙景奕 府晓丹

中国医科大学学报2012,Vol.41Issue(2):120-123,127,5.
中国医科大学学报2012,Vol.41Issue(2):120-123,127,5.

缺氧复氧对乳鼠心肌细胞的损伤的研究

Effect of Anoxia/Reoxygenation on the Injury of Rat Myocardial Cells

侯志文 1于波 1孟凡吉 1孙景奕 1府晓丹1

作者信息

  • 1. 中国医科大学附属第一医院心内科,沈阳110001
  • 折叠

摘要

Abstract

Objective To investigate the injury in rat myocaidial cells under anoxia (A) and the change of neonatal rat myocaidial cells injury under anojria( A)/ reoxygenation( AR) at various time points. Methods The effect of A and A/Ron survival rate of different neonatal rat myocaidial cells at various times was detected by MTT assay and the degree of cell injury under A and A/R at various times was detected by LDH,T-SOD,GSH/GSSG detection kit. Results Compared with the control group,the injury could be detected in A and A/R groups, and the injury stabilized at 1 hour after reoxygenation. Conclusion Neonatal rat myocaidial cells injury under anoxia (A)/ reoxygenation (AR) stabilized at 1 hour after reoxygenation.

关键词

心肌细胞/缺氧复氧/损伤

Key words

myocaidial cells/ anoxia/reoxygenation/ injury

分类

医药卫生

引用本文复制引用

侯志文,于波,孟凡吉,孙景奕,府晓丹..缺氧复氧对乳鼠心肌细胞的损伤的研究[J].中国医科大学学报,2012,41(2):120-123,127,5.

基金项目

辽宁省教育厅高校科研计划(2008804),辽宁省科技计划项目(2007408001-3) (2008804)

中国医科大学学报

OA北大核心CSCDCSTPCD

0258-4646

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