中国医科大学学报2012，Vol.41Issue(3)：247-249,261,4.
尿NGAL和KIM-1在儿童急性肾损伤中的改变及临床意义
Changes of Urinary Neutrophil Gelatinase-associated Lipocalin and Kidney Injury Molecule-1in Children with Acute Kidney Injury
摘要
Abstract
Objective To determine the function of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) in children acute kidney injury (AKI) prediction. Methods A prospective single-center evaluation of urinary biomarkers was performed in a cohort of children who presented to Shengjing Hospital Pediatric Clinic and Emergency center from June 2009 to December 2010. Patients were included if the physician ordered a serum creatinine and had been done serum creaunine within one year. Patients with a known diagnosis of chronic kidney disease were excluded. Five mL of urine was obtained for assessment of NGAL and KIM-1 by ELISA method. Patients were classified by the pediatric modified RIFLE (pRTFLE) criteria for AKI. The primary diagnosis and length of hospital-izab'on were also recorded. Results A total of 552 patients were enrolled in the study,316 patients were hospitalized,59 patients were diagnosed AKI. Patients with AKI had a significantly elevated mean urinary NGAL and KIM-1 level compared with normal kidney function patients. AKI-F patients had the highest value of urinary NGAL and KIM-1 and significant statistical difference was found when comparing with normal groups (329.1±366.2,13.9±12.7,and 1129.0±1018.7,280.2±218.6,P < 0.001). These values were superior to those for NAG and serum creatinine. Some patients with AK1-R and AKI-I had normal value of serum creaunine and significantly elevated urinary NGAL and KIM-1. The length of hospitalization for the children was correlated with the severity of AKI. Conclusion Pediatric AKI is not only caused by kidney disease but also by other diseases. Urinary NGAL and KIM-1 were significantly elevated in the children with early stage AKI,which may serve well to detect AKI accurately even in cases where serum creatinine levels are normal.关键词
中性粒细胞明胶酶相关脂质运载蛋白/肾损伤分子1/儿童/急性肾损伤Key words
neutrophil gelatinase-associated lipocalin/ kidney injury molecule-1/ children/ acute kidney injury分类
医药卫生引用本文复制引用
杜悦,崔家鹏,侯玲,郭金杰,赵成广,吴玉斌..尿NGAL和KIM-1在儿童急性肾损伤中的改变及临床意义[J].中国医科大学学报,2012,41(3):247-249,261,4.基金项目
辽宁省自然科学基金资助项目(201102288) （201102288）
