中国药理学通报2012，Vol.28Issue(4)：461-465,5.DOI:10.3969/j.issn.1001-1978.2012.04.005
β-抑制蛋白在AT1受体信号通路中的作用及意义
Roles of β-arrestins in signaling pathway of AT1 receptor
摘要
Abstract
Angiotensin II . the most important active substance of renin-angiotensin system, is one of the vital regulatory factors in cardiovascular system. After binding with its receptor, angiotensin 0 activates complicated signal network and participates in various physiological and pathological progresses. β-arrestins, which are ubiquitously expressed in cardiovascular system, are a family of multi-functions proteins that play a role of negativefeedback regulation of G protein-coupled receptors. This paper reviewed the important roles of β-arrestins in signaling pathway of angiotensin II type 1 ( AT,) receptor induced by angiotensin fl.关键词
β-抑制蛋白/血管紧张素Ⅱ/AT1受体/信号通路/脱敏/内化Key words
β-arrestins/ angiotensin II/ AT, receptor/ signaling pathway/ desensitization/ intemalization分类
医药卫生引用本文复制引用
魏凯,徐添颖,管云枫,缪朝玉..β-抑制蛋白在AT1受体信号通路中的作用及意义[J].中国药理学通报,2012,28(4):461-465,5.基金项目
国家重点基础研究发展计划(973计划)资助课题(No2009CB521902) （973计划）
国家科技重大专项"重大新药创制"(No2009ZX09303-002) （No2009ZX09303-002）
