中国药理学通报2012，Vol.28Issue(4)：469-472,4.DOI:10.3969/j.issn.1001-1978.2012.04.007
金属配合物与G-四链体作用的研究进展
Interaction of metal complexes with G-quadruplex
摘要
Abstract
The activity of telomerase can be prohibited by the secondary structure of the telomere DNA-G-quadruplex formed by the single chain in G-rich field, resulting in the apoptosis in tumor cells. Compound which can induce the formation or stabilize the structure of G-quadruplex might be potential anticancer drug. The relative ease of synthesis, the variable structure and the positively charged center enable the metal complexes to in-teract with the grooves and loops of the quadruplex and negatively charged phosphates backbone. Therefore, many metal complexes have been designed and synthesized. This paper reviews the discoveries in the interaction of G-quadruplex with metal complexes in the past years.关键词
金属配合物/端粒酶抑制剂/DNA/G-四链体/致癌基因/抗肿瘤药物Key words
metal complexes/ telomerase inhibitor/ DNA G-quadruplex/oncogene/ anti-tumor drugs分类
医药卫生引用本文复制引用
孙静,陈嘉曦,陈伙炎,毛宗万..金属配合物与G-四链体作用的研究进展[J].中国药理学通报,2012,28(4):469-472,4.基金项目
国家自然科学基金资助项目(No 21101034) （No 21101034）
东莞市科技计划项目(No 2011108102046) （No 2011108102046）
