中国药理学通报2012，Vol.28Issue(4)：577-580,4.DOI:10.3969/j.issn.1001-1978.2012.04.031
核黄素四丁酸酯抗焦虑作用的药效学研究
Anxiolytic effects of riboflavin tetrabutyrate
于文潇 1赵德 2邓君1
作者信息
- 1. 西南大学药学院,重庆400716
- 2. 北大国际医院集团重庆大新药业股份有限公司,重庆400700
- 折叠
摘要
Abstract
Aim To study anxiolytic effect of riboflavin tetrabutyrate ( RTB). Methods Mice were used as experimental animals and diazepam and buspirone as positive reference drugs. The anxiolytic effect of RTB was evaluated by elevated plus-maze ( EPM) model and novel food consumption test. The effect of RTB on the muscle coordination was determined by RotaRod System. Results RTB did not influence the total entries into EPM arms of mice. However, at the dose of 20 and 40 mg ? kg-1 (po), RTB increased the pecent-ages of OE and OT significantly in the model of EPM. At the dose of 40 and 80 mg ? kg-1, RTB increased the consumption of novel food ( mg ? g-1) significantly. Meanwhile, RTB decreased the falling rate of mice from the rota-rod test in contrast with the positive reference drugs. Conclusion RTB has anxiolytic activity, but does not impair sports coordination.关键词
核黄素四丁酸酯/抗焦虑/行为药理学/高架十字迷宫/新型食物消耗实验/转棒实验Key words
riboflavin tetrabutyrate/anxiolytics/behavioral pharmacology/ elevated plus-maze/ novel food consumption/ rota-rod test分类
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于文潇,赵德,邓君..核黄素四丁酸酯抗焦虑作用的药效学研究[J].中国药理学通报,2012,28(4):577-580,4.
