中国药理学通报2012，Vol.28Issue(6)：754-756,3.DOI:10.3969/j.issn.1001-1978.2012.06.005
肼引发损伤相关小分子代谢物的研究进展
Research advances in metabolites related with hydrazine toxicity based on metabonomics
摘要
Abstract
Hydrazine is an important intermediate both in industrial synthetic chemistry and pharmaceutical production. It is also the common metabolite of hydrazine medicine. Hydrazine induces hepatotoxicity, nephrotoxicity and neurotoxicity, which is a severe health menace to human being. As life science develops , metabonomics can obtain global and comprehensive changes of metabolites, response to toxicity. It has been used for revealing the endogenous metabolites disorder after exogenous hydra-zine stimulation and finding special biological function of potential biomarkers related to hydrazine. This article focuses on the research progress of metabolites related with hydrazine toxicity based on metabonomics in recent years, which would provide I-deas for mechanisms, early discovery and therapy of hydrazine toxicity.关键词
肼/肝毒性/肾毒性/中枢神经毒性/代谢组学/内源性小分子代谢物/生物功能Key words
hydrazine/ hepatotoxicity/ nephrotoxicity/ neurotoxicity / metabonomics/ endogenous metabolites/ biological function分类
医药卫生引用本文复制引用
安卓玲,李鹏飞,迟小华,张茜,马萍,刘丽宏..肼引发损伤相关小分子代谢物的研究进展[J].中国药理学通报,2012,28(6):754-756,3.基金项目
国家自然科学基金资助项目(No 81100283) （No 81100283）
中国博士后科学基金会资助项目(No 20110491891) （No 20110491891）
