中国真菌学杂志2012，Vol.7Issue(1)：4-7,4.
覆盆子提取物联合唑类药物抗真菌活性研究
Combination antifungal activity of ethanol extracts from Rubus idaeus and antifungal azoles
张石群 1林辉 2苗琦 1刘伟 2曹永兵 1姜远英2
作者信息
- 1. 第二军医大学药学院药理学教研室,上海200433
- 2. 福建中医药大学药学院中药教研室,福州350108
- 折叠
摘要
Abstract
Objective To investigate the antifungal activity of extracts from Rubus idaeus combined with azole drugs against Candida spp. In vitro . Methods The minimum inhibitory concentration (MIC), the fractional inhibitory concentration index (FICI) of extracts hom Rubus idaeus and combination with azole drugs against Candida spp. Were determined by M27-A Microdilution Method based on CLSI. Results All extracts from Rubus idaeus by different solution methods showed collaboration with fluconazole. For example, the MIC80 of ethanol extracts from Rubus idaeus against Candida spp. Mainly concentrated on 0. 16 ～ 1. 25 mg/mL, while combined with fluconazole showed the collaboration (FICI≤0.5), and the MIC80 reduced to 0.01 -0.04 mg/mL. The antifungal effect of fluconazole against Candida spp. Was also strengthened. Besides, the MIC80 of ethanol extracts from Rubus idaeus were also reduced from 10 mg/mL to 0.04 mg/mL when being combined with other azole drugs. Conclusion The antifungal effect of ethanol extracts from Rubus idaeus or azole drugs against resistant Candidas was weaker, while the combination showed clear collaboration and the effect against resistant Candida spp. Significantly enhanced.关键词
覆盆子/醇提物/体外抗真菌活性/部分抑菌浓度指数(FICI)Key words
Rubus idaeus /ethanol extracts/ in vitro antifungal activity/fractional inhibitory concentration index (FICI)分类
医药卫生引用本文复制引用
张石群,林辉,苗琦,刘伟,曹永兵,姜远英..覆盆子提取物联合唑类药物抗真菌活性研究[J].中国真菌学杂志,2012,7(1):4-7,4.
