摘要
Abstract
Objective To investigate the effect of Shenfu Injection on hemodynamics and blood gas analysis in patients undergoing lobectoiny oi lung combined thoracic epidural block and general anesthesia.Methods A double blind trail was conducted on 60 patients undergoing lobectomy of lung combined thoracic epidural block and general anesthesia.The patients were randomly divided into Shenfu Injection group (n=30) and control group (n=30). In the Shenfu Injection group, 1.5 mL/kg Shenfu Injection diluted with 250 mL saline were given before anesthesia introduction. In the control group, equal saline were given at the same time. The following indexes were observed: (1) MAP,HR and CVP at the time before anesthesia introduction (TO), after anesthesia introduction for 5 minutes(T1), surgical exploration(T2),after one-lung ventilation for 30 minutes(T3), after one-lung ventilation for 60 minutes(T4), rinse chest(T5) and the end of operation(T6).(2)the dose of atropine and ephedrine, the amount of intraoperative transfusion,blood loss, urine volume and duration of surgery.(3) the dose of ropivacaine, propofol, fentanyl and vecuronium; (4)the blood gas analysis was detected at the time of T1, T3,T4 and T6. Results Compared with the control group, MAP and HR increased at the time of T1、T2、T3、T4 and T5 (p<0.05), the amount of intraoperative transfusion, the dose of atropine and ephedrine were lower (p< 0.05), PaC>2 increased at the time of T3 and T4 (p<0.05)in Shenfu Injection group .There wre no diference in the other observation indexes(p>0.05). Conclusion Shenfu Injection reflects a stable effect on hemodynam-ics in patients undergoing lobectomy of lung combined thoracic epidural block and general anesthesia,and a better outcome on the blood gas analysis in duration of one-lung ventilation.关键词
参附注射液/肺叶切除手术/血流动力学/血气分析/复合全麻Key words
Shenfu injection/Pulmonary surgical procedures/Hemodynamics/Blood gas analysis/Combined general anesthesia分类
医药卫生
