中国中西医结合外科杂志2012，Vol.18Issue(3)：248-250,3.DOI:10.3969/j.issn.1007-6948.2012.03.009
舒芬太尼在肝脏手术后自控皮下镇痛的作用
Effects of Patient-controlled Subcutaneous Analgesia with Sufentanil after Liver Surgery
摘要
Abstract
Objective To investigate the analgesic effect and influence on plasma cortisol among different dosages of sufentanil by patient-controlled subcutaneous analgesia(PCSA) following liver surgery. Methods Forty five patients following liver surgery were randomized into three groups, Groups A,B and C received sufentanil 3.0 μg/kg, 3.5 μg/kg and 3.8 μg/kg with PCSA respectively , the different dosages of sufentanil were diluted with 2% lidocaine hydrochloride 200 mg in 100 mL of normal saline in PCSA. The visual analogue scale at rest and cough, Ramsay scores, and side effects happening at 3,8,24,48 and 72 h of postoperation were observed and evaluated.Venous blood samples were taken before surgery and after surgery to determine the concentration of plasma cortisol. Results Compared with Groups C at 8 h to 72 h of post-operation, there were significant differences in VASr Groups A and Groups B(p<0.05), but in VASc, significant differences could be seen in Groups A(p<0.05). Compared with Groups C Postoperative Ramsay scores: There were significant differences at 8h to 48h of postoperation in Groups A and Groups B(P < 0.05). The concentration of plasma cortisol was higher after surgery than before surgery in Groups A(p<0.05), and compared with Groups C, there were significant differences after surgery in Groups A(p< 0.05),but no difference could be seen in Groups B(p>0.05). Conclusion Sufentanil 3.5 μg/kg with patient-controlled subcutaneous analgesia after liver surgery was valuable, with fewer side-effects by inducing remission of the stress reaction of the patient in the postoperative period.关键词
舒芬太尼/皮下镇痛/肝脏手术/皮质醇Key words
Sufentanil/Subcutaneous analgesia/Liver surgery/Cortisol分类
医药卫生引用本文复制引用
张宏利,雷龙,肖旺频..舒芬太尼在肝脏手术后自控皮下镇痛的作用[J].中国中西医结合外科杂志,2012,18(3):248-250,3.基金项目
浙江省嘉兴市科技局资金项目(2011AY1049-8) （2011AY1049-8）
