Effect of environmental factors on chemoresistance of HepG2 cells by regulating hypoxia-inducible factor-1αOACSCDCSTPCD
Effect of environmental factors on chemoresistance of HepG2 cells by regulating hypoxia-inducible factor-1α
Background Accumulating evidence demonstrates that the microenvironment of the host has an important effect on the chemoresistance of tumors.We also found that the formation of intrinsic multidrug resistance is related to environmental factors that are common with tumor growth of hepatocellular carcinoma.The aim of this study was to explore the molecular mechanisms by which multidrug resistance of hepatocellular carcinoma is induced by the microenvironment.i…查看全部>>
ZHU Hong;LUO Shun-feng;WANG Ji;LI Xin;WANG Hui;PU Wang-yang;ZHANG Hong;ZHUANG Zhi-xiang
Department of Oncology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, ChinaHepatic Surgery Center, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, ChinaDepartment of Oncology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, ChinaDepartment of Oncology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, ChinaDepartment of Oncology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, ChinaDepartment of Oncology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, ChinaDepartment of Oncology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, ChinaDepartment of Oncology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
HepG2 cellshypoxia-inducible factor-1αchemoresistance
HepG2 cellshypoxia-inducible factor-1αchemoresistance
《中华医学杂志（英文版）》 2012 (6)
ISG15-泛素-26S蛋白酶体通路在肝癌转移无能中的作用
1095-1103,9
This work was supported by grants from Suzhou City Research Foundation for Applied Basic Research (No.YJS0930),Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No.10KJB320020),National Natural Science Foundation of China (No.81000944) and Research Foundation for "Reserved Academic Leader" from the Second Affiliated Hospital of Soochow University.
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