首页|期刊导航|中华医学杂志（英文版）|Expression of the recepteur d'originenantais receptor tyrosine kinase in non-small cell lung cancer and its clinical significance

Expression of the recepteur d'originenantais receptor tyrosine kinase in non-small cell lung cancer and its clinical significance

HAN Wei-li LI Wei-dong HU Jian RUSIDANMU Aizemaiti CHEN Ling-fang SHEN Ling ZHENG Shu-sen

中华医学杂志（英文版）2012，Vol.125Issue(6)：1110-1114,5.

中华医学杂志（英文版）2012，Vol.125Issue(6)：1110-1114,5.DOI:10.3760/cma.j.issn.0366-6999.2012.06.026

Expression of the recepteur d'originenantais receptor tyrosine kinase in non-small cell lung cancer and its clinical significance

HAN Wei-li ¹LI Wei-dong ¹HU Jian ¹RUSIDANMU Aizemaiti ¹CHEN Ling-fang ²SHEN Ling ²ZHENG Shu-sen³

作者信息

1. Department of Thoracic and Cardiovascular Surgery,First Affiliated Hospital,Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
2. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,First Affiliated Hospital,Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
3. Department of Surgery, First Affiliated Hospital,Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
折叠

摘要

Abstract

Background Recepteur d'originenantais (RON) is a receptor tyrosine kinase (RTK) that belongs to the MET proto-oncogene family.The aim of this study was to investigate the expression of RON receptor tyrosine kinase in human non-small cell lung cancer (NSCLC) and its relationship with clinical pathology of NSCLC and prognosis.Methods RON protein expression by immunohistochemistry (IHC) in 96 NSCLC specimens was evaluated and compared with the clinical pathology and prognosis,and 20 para-neoplastic tissues were included as controls.RON mRNA and protein expression in 25 fresh tissue samples of lung cancer and 10 normal lung tissues were also analyzed by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting.Results The rate of positive RON expression differed significantly between NSCLC tissues (55.2％,53/96) and para-neoplastic tissues (5％,1/20) (P ＜0.001).RON protein expression was not found to be associated with gender or age.However,RON expression positively correlated with clinical TNM stage (P=0.004),histological types (P=0.001),lymph node metastasis (P=0.012) and differentiation (P=0.035).RT-PCR and Western blotting analysis also confirmed that the expression of RON mRNA and protein was significantly increased in the NSCLC tissues versus normal tissues.In addition,RON expression was associated with a poor prognosis for patients with NSCLC (P=0.045).Conclus1ons The expression of RON protein and mRNA is significant in human NSCLC and low in para-neoplastic and normal tissues.Elevated RON expression may contribute to the occurrence,progression and metastasis of NSCLC,inferring that it could be useful as a new prognostic indicator for patients with NSCLC.

关键词

non-small cell lung cancer/RON/receptor tyrosine kinase/immunohistochemistry/prognosis

Key words

non-small cell lung cancer/RON/receptor tyrosine kinase/immunohistochemistry/prognosis

引用本文复制引用

HAN Wei-li,LI Wei-dong,HU Jian,RUSIDANMU Aizemaiti,CHEN Ling-fang,SHEN Ling,ZHENG Shu-sen..Expression of the recepteur d'originenantais receptor tyrosine kinase in non-small cell lung cancer and its clinical significance[J].中华医学杂志（英文版）,2012,125(6):1110-1114,5.

基金项目

This project was supported by grants from the Natural Science of Zhejiang Province (No.Y207419),and Science and Technology Project of Zhejiang Province (No.2009C33150),and the project from Department of Education of Zhejiang Province (No.20061911). （No.Y207419）

中华医学杂志（英文版）

OACSCDCSTPCD

ISSN：0366-6999

访问量0

下载量0

段落导航