首页|期刊导航|中华医学杂志（英文版）|Treatment of respiratory failure in metastatic pulmonary choriocarcinoma: an experience at Peking Union Medical College Hospital, China
中华医学杂志（英文版）Issue(7)：1214-1218,5.DOI:10.3760/cma.j.issn.0366-6999.2012.07.005
Treatment of respiratory failure in metastatic pulmonary choriocarcinoma: an experience at Peking Union Medical College Hospital, China
Treatment of respiratory failure in metastatic pulmonary choriocarcinoma: an experience at Peking Union Medical College Hospital, China
摘要
Abstract
Background Respiratory failure caused by metastatic pulmonary chodocarcinoma usually develops rapidly and is associated with a high mortality.The clinical management strategy is important in choriocarcinoma patients with acute respiratory failure.The objective of this study was to evaluate the clinical characteristics,treatment outcome and potential risk factors in patients with acute respiratory failure from metastatic pulmonary choriocarcinoma.Methods Sixteen patients with acute respiratory failure from pulmonary metastases choriocarcinoma were enrolled and treated at Peking Union Medical College Hospital from 1995 to 2010.Clinical characteristics,causes of pulmonary failure,treatment profiles and outcomes were analyzed retrospectively.Results The presence of respiratory infection or hemorrhage was associated with acute respiratory failure in patients with metastatic choriocarcinoma.Fifteen (93.8％) patients presented with pulmonary infection,8 (50.0％) patients with pulmonary hemorrhage.All patients were treated with face mask or mechanical ventilation.Fourteen (87.5％) patients received initial chemotherapy at a low dosage or with modified regimens,with a median of 2 cycles (range 1 to 4).Seven patients achieved a complete remission (CR),two had a partial remission.Six CR patients remained alive with a median follow-up of 59 months (range 16 to 120).Seven patients developed progressive diseases and subsequently died.Conclusions Respiratory infection and hemorrhage were associated with acute respiratory failure in metastatic pulmonary choriocarcinoma.The initial administration of gentle chemotherapy regimens,accompanied with mechanical ventilation,is feasible andeffective in attenuating respiratory failure in patients with metastatic pulmonary chodocarcinoma.关键词
choriocarcinoma/chemotherapy/pulmonary metastasis/respiratory failure/mechanical ventilationKey words
choriocarcinoma/chemotherapy/pulmonary metastasis/respiratory failure/mechanical ventilation引用本文复制引用
SHEN Yun,REN Tong,FENG Feng-zhi,WAN Xi-run,XIANG Yang..Treatment of respiratory failure in metastatic pulmonary choriocarcinoma: an experience at Peking Union Medical College Hospital, China[J].中华医学杂志（英文版）,2012,(7):1214-1218,5.基金项目
This study was supported by a grant from the Key Projects in the National Science & Technology Pillar Program in the llth 5-Year Plan (No.2008BAI57B05). （No.2008BAI57B05）
